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Nanda, R. K.

• Adoption of Poplar-based Agroforestry as an Approach for Diversified Agriculture in Punjab

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Authors

Sanjeev K. Chauhan , R. K. Nanda , M. S. Brar

Source

Indian Forester, Vol 135, No 5 (2009), Pagination: 671-677

Abstract

Agroforestry that envisages integration of trees, herbaceous crops and/or animals on the same land unit, holds promising potential in Punjab to diversify traditional rice-wheat rotation. On the basis of information provided by the respondents, it was realized that the farmers with low awareness, unfavourable attitude and constraints (land, technical, financial, legal, social, etc.) are not able to adopt poplar (Populus deltoides)-based agroforestry successfully. In poplar-wheat agroforestry system, growing condition of wheat are modified due to presence of tree and, thus, response of wheat differs than that of tree-less agricultural system. Age of poplar trees is recorded as most important factor influencing wheat grain (var. PBW 343) yield. On an average, reduction in grain yield was 20.10 per cent under one year old poplar plantation, which increased to 54 per cent under four year old plantation. Under irrigated poplar-based agro-ecosystem, light is the major limiting factor for reduction in grain yield.

Keywords

Poplar-Based Agroforestry, Diversified Agriculture, Punjab

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• Simultaneous Spectrophotometric Estimation of Enalapril Maleate and Losartan Potassium in Tablet Dosage form and It's Application to Dissolution Study

Abstract Views :191  |  PDF Views:82

Authors

A. B. Thomas ¹, A. A. Chaudhari ¹, R. K. Nanda ¹, L. P. Kothapalli ¹, U. B. Chavan ¹, A. D. Deshpande ¹

Affiliations
1 Department of Pharmaceutical chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune - 411 018, Maharashtra, IN

Source

Journal of Pharmaceutical Research, Vol 8, No 2 (2009), Pagination: 85-88

Abstract

Two spectrophotometric methods have been developed for the simultaneous estimation of Enalapril Maleate (Ena) and Losarton Potassium (Los) in combined tablet dosage forms. The first method involves determination using the absorbance correction method, the sampling wavelengths selected are, 222 nm and 250 nm over the concentration ranges of 2-32 mcg/mL and 1-60 mcg/mL for Ena and Los respectively. The second method is the second order derivative method, the sampling wavelength selected for estimation of Ena and Los are 219.5 nm and 264 nm which show linearity in the concentration ranges of 2-32 mcg/mL and 1-60 mcg/mL respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. Also the developed methods were successfully employed for dissolution studies in tablet dosage form.

Keywords

Enalapril, Losartan, Absorbance Correction Method, Second Order Derivative Method, Dissolution Studies.

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• Simultaneous Spectrophotometric Estimation of Hydrochlorothiazide, Atenolol and Losartan Potassium in Tablet Dosage Form

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Authors

A. B. Thomas ¹, U. B. Chavan ¹, R. K. Nanda ¹, L. P. Kothapalli ¹, A. D. Deshpande ¹

Affiliations
1 Department of Pharmaceutical chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, IN

Source

Journal of Pharmaceutical Research, Vol 8, No 3 (2009), Pagination: 139-141

Abstract

Two UV spectrophotometric methods have been developed for the simultaneous estimation of Hydrochlorothiazide (Hctz), Atenolol (Atn) and Losartan Potassium (Los) in combined tablet dosage forms. The first method involves determination using the Area under curve, the sampling wavelength intervals selected are 274.5-270.5 nm, 226-222 nm and 252-248 nm over the concentration ranges of 0.5-30 mcg mL^-1, 1-50 mcg mL^-1 and 1-60 mcg mL^-1 for Hctz, Atn and Los respectively. The second method involves determination using the multicomponent mode of the UV visible spectrophotometer, the sampling wavelengths selected are 272.5 , 224 and 250 nm over the concentration ranges of 0.5-30 mcg mL^-1, 1-50 mcg mL^-1 and 1-60 mcg mL^-1 for Hctz, Atn and Los respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. The developed methods are simple, rapid, precise, accurate and can be employed for the routine estimation of Hydrochlorothiazide, Atenolol and Losartan Potassium in both bulk and tablet dosage form.

Keywords

Hydrochlorothiazide, Atenolol, Losartan Potassium, Area under Curve Method, Multicomponent Mode Method.

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• Simultaneous Spectrophotometric Methods for Estimation of Cefpodoxime Proxetil and Potassium Clavulanate in Tablet Dosage form

Abstract Views :194  |  PDF Views:82

Authors

A. B. Thomas ¹, S. B. Dighe ¹, L. P. Kothapalli ¹, R. K. Nanda ¹, S. N. Jagdale ¹, A. D. Deshpande ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pad. Dr. D.Y.Patil Institute Of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, Maharashtra, IN

Source

Journal of Pharmaceutical Research, Vol 9, No 4 (2010), Pagination: 167-171

Abstract

Three UV spectrophotometric methods have been developed for the simultaneous estimation of Cefpodoxime proxetil (Cef) and Potassium clavulanate (Pot.clav.) in combined tablet dosage forms. The first method involves Q-absorbance ratio method, the sampling wavelengths selected are, 315.0nm (isoabsorptive point) and 233.0 nm (lmax of Cef). The second method is the First order derivative method, the sampling wavelengths selected are 269.0 nm and 240.0 nm for estimation of Cef and Pot.clav. respectively. In both the methods, the linearity range for both Cef and Pot.clav. was in the concentration range of 1.5-50 μg mL^-1. The third method based on ratio derivative spectrophotometry, involves measurement of absorbances at the amplitudes in the first order derivative of the ratio spectra at 246.0 nm and 327.0 nm for Cef and Pot.clav. respectively over the concentration range of 2.5-50 μg mL^-1for both the drugs. The results of the analysis were validated statistically and recovery studies carried out as per ICH guidelines. The developed methods are rapid, precise, accurate, rugged and can be employed for the routine estimation of Cefpodoxime proxetil and Potassium clavulanate in both bulk and tablet dosage form.

Keywords

Cefpodoxime Proxetil, Potassium Clavulanate, Q-Absorbance Ratio Method, First Order Derivative Spectroscopy, Ratio Spectra Derivative Spectrophotometry.

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• Stability Indicating Hptlc Method for the Simultaneous Determination of Amlodipine Besylate and Telmisartan from Tablet Dosage Form

Abstract Views :218  |  PDF Views:86

Authors

A. B. Thomas ¹, S. N. Jagdale ¹, R. K. Nanda ¹, L. P. Kothapalli ¹, A. D. Deshpande ¹

Affiliations
1 Pad.Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune-18, Maharashtra, IN

Source

Journal of Pharmaceutical Research, Vol 10, No 2 (2011), Pagination: 66-72

Abstract

Amlodipine besylate and Telmisartan are used in the treatment of hypertension. A simple, selective and stability indicating High-performance thin-layer chromatography method has been established for the simultaneous analysis of Amlodipine besylate and Telmisartan. The method uses aluminum-backed silica gel 60F₂₅₄ TLC plates as stationary phase with ethyl acetate: methanol: ammonia: glacial acetic acid [7.5:1.5:1.0:0.2 (v/v/v/v)] as mobile phase. Densitometric analysis was carried out in the absorbance mode at 226 nm. This system was found to give compact bands for Amlodipine besylate and Telmisartan with Rf values of 0.34±0.02 and 0.60±0.02 respectively. Linear relationships were obtained between response and amount of drug with high correlation coefficients (r²) in the range 500-6000 ng band^-1 for Amlodipine besylate (r²=0.9951) and 1000-8000 ng band^-1 for Telmisartan (r²= 0.9982). The method was validated for precision, accuracy and robustness as per ICH guidelines. Amlodipine besylate and Telmisartan were subjected to acid, base, oxidation, dry heat, wet heat and photo degradation studies. The degradation products obtained were well resolved from the pure drugs with significantly different Rf values. As the method could effectively separate the drugs from its degradation products, it can be used for stabilityindicating analysis.

Keywords

Amlodipilne Besylate, Telmisartan, HPTLC.

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• Estimation of Nateglinide and Metformin Hydrochloride in Tablet Dosage form by Spectrophotometric Methods

Abstract Views :160  |  PDF Views:89

Authors

A. B. Thomas ¹, S. D. Patil ¹, L. P. Kothapalli ¹, R. K. Nanda ¹, S. S. Bhosle ¹, A. D. Deshpande ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, IN

Source

Journal of Pharmaceutical Research, Vol 10, No 3 (2011), Pagination: 102-105

Abstract

Three UV spectrophotometric methods have been developed for the simultaneous estimation of Nateglinide (Nat) and Metformin hydrochloride (Met) in combined tablet dosage form. The first method is the Area under curve method, the sampling wavelength ranges selected for estimation of Nat and Met are 214-216 nm and 231-235 nm respectively with linearity in the concentration ranges of 0.5-80 μg /ml and 0.5-40 μg/ ml respectively. Second method involves determination using the Multicomponent mode of the UV visible spectrophotometer, the sampling wavelengths selected are 216 nm and 233nm over the concentration range 0.5-80 μg/ml and 0.5-40 μg/ml for Nat and Met respectively. The third method is the second order derivative method, the sampling wavelengths selected for estimation of Nat and Met are 225 nm and 234 nm with linearity in the concentration range 1-70 μg/ml and 1-40 μg/ml respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. The developed methods are simple, rapid, precise, accurate and can be employed for the routine estimation of Nateglinide and Metformin hydrochloride in both bulk and tablet dosage form.

Keywords

Nateglinide, Metformin Hydrochloride, Area under Curve Method, Multicomponent Mode, Second Order Derivative.

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• Estimation of Drotaverine and Omeprazole in Combined Dosage form by Spectrophotometric Methods

Abstract Views :159  |  PDF Views:80

Authors

L. P. Kothapalli ¹, V. C. Dewoolkar ¹, V. A. Hurne ¹, A. B. Thomas ¹, R. K. Nanda ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Padm. Dr.D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, Maharashtra, IN

Source

Journal of Pharmaceutical Research, Vol 9, No 3 (2010), Pagination: 126-129

Abstract

Two simple, precise, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Drotaverine HCl (DRO) and Omeprazole (OME) in combined tablet dosage form. The first method is the Area under curve method, the sampling wavelength range selected for estimation of drotaverine and omeprazole are 227.5-231.5 nm and 300.0-304.0 nm respectively with linearity in the concentration ranges of 4-24 mg /ml and 1-6 mg/ml respectively. Second method is based on two wavelength calculations, wavelengths selected for estimation of drotaverine were 300.0 nm and 304.0 nm and for Omeprazole were 279.5 nm and 290.5 nm over the concentration ranges of 4-16 mg/ml and 1-6 mg/ ml for drotaverine and omeprazole respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.

Keywords

Drotaverine, Omeprazole, Area under Curve Method, Two-Wavelength Method, ICH Guidelines.

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• Stability-Indicating Validated HPTLC Method for Simultaneous Estimation of Atazanavir Sulfate and Ritonavir in Pharmaceutical Dosage Form

Abstract Views :206  |  PDF Views:0

Authors

R. K. Nanda ¹, Pradeep B. Yadav ¹, A. A. Kulkarni ¹

Affiliations
1 Padmashri Dr.D.Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-411018, Maharashtra, IN

Source

Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1381-1384

Abstract

A high-performance thin layer chromatography (HPTLC) method for Atazanavir Sulfate (ATV) and Ritonavir (RTV) was developed in the present work. The mobile phase selected was Ethyl acetate: Toluene: methanol (7.5: 2: 0.5 v/v/v) with UV detection at 234 nm. The standard solution ranging from 1000-7000ng/band was applied for ATV and standard solution ranging from 500-3500ng/band was applied for RTV. Linearity was observed in this concentration range on precoated silica gel 60 F₂₅₄ TLC plate in the form of bands with 100 μl sample syringe using automatic sample applicator LINOMAT V. After development, plate was immediately dried and was observed under UV chamber. The well resolved bands of drugs were scanned with Camag TLC scanner III densitometer controlled by WINCAT's software version 4. Retention factor for ATV and RTV were found to be 0.76 ± 0.95 and 0.54 ± 1.43 respectively. Drugs were subjected to oxidation, acid hydrolysis, base hydrolysis and sun light to apply stress condition for degradation studies. Results of analysis were validated statistically and by recovery studies.

Keywords

Atazanavir Sulfate, Ritonavir, and HPTLC.

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• Development and Validation of a HPLC Method for Simultaneous Analysis of Aspirin and Atorvastatin Calcium as the Bulk Drugs and in the Capsule Dosage Form

Abstract Views :206  |  PDF Views:1

Authors

R. K. Nanda ¹, S. E. Potawale ¹, V. V. Bhagwat ¹, S. C. Hamane ¹, R. S. Deshmukh ²

Affiliations
1 D.Y.Patil Pratishthan’s Padmashree Dr. D.Y.Patil Institute of Pharmaceutical, Sciences and Research, Pimpri, Pune-411018, IN
2 Sinhgad College of Pharmacy, Vadgaon, Pune-411041, IN

Source

Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 961-964

Abstract

A simple, precise, accurate and rapid HPLC method has been developed, and validated for the determination of Aspirin, Atorvastatin Calcium simultaneously, in combined dosage form. Acetonitrile: 0.02 M Phosphate buffer with pH 6.1 (50%:50% v/v) is used as the mobile phase, pH adjusted with Sodium Hydroxide (1% aqueous). Mobile phase was delivered at the flow rate of 1.0 ml/min., 239 nm is the detection wavelength for this study. The applicability of the method for simultaneous determination of Aspirin, Atorvastatin Calcium was verified by the determination of these compounds in marketed capsules. Results of the analysis were validated statistically, and by recovery studies. Linearity for Aspirin And Atorvastatin Calcium was in the range of 5-35 μg/ml and 1-7 μg/ml, respectively and reproducibility was found to be satisfactory. The % assay (Mean±S.D.) was found to be 99.33±0.501 and 101.4±0.18 for Aspirin and Atorvastatin Calcium respectively. The recovery and RSD values are within the limits given in ICH guide lines. Method development indicates the suitability of proposed method for the routine determination of these compounds in capsule dosage form. The proposed method can be successfully used to determine the drug contents of marketed formulation.

Keywords

RP-HPLC, Validation, Aspirin, Atorvastatin.

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• Development and Validation of a HPTLC Method for Simultaneous Densitometric Analysis of Cefixime and Potassium Clavulanate as the Bulk Drugs and in the Tablet Dosage Form

Abstract Views :177  |  PDF Views:0

Authors

R. K. Nanda ¹, V. V. Bhagwat ¹, S. E. Potawale ¹, S. C. Hamane ¹

Affiliations
1 Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, IN

Source

Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 998-1001

Abstract

A new simple high performance thin layer chromatographic (HPTLC) method for simultaneous determination of Cefixime and Potassium Clavulanate combined tablet dosage form has been developed and validated. The separation was carried out on Merck aluminum plates precoated with silica gel 60 F₂₅₄, using Acetone: Water: Acetic acid 8:0.8:1.2 (v/v/v) as mobile phase. The separated spots were stained with Iodine vapors and scanned at 410 nm. The retention factor for Cefixime and Potassium Clavulanate were found to be 0.23±0.01 and 0.68±0.01. The method was validated with respect to linearity, accuracy, precision, robustness, in accordance with ICH guidelines. The calibration curve was found to be linear over a range of 0.5-3.0 μg per spot for Cefixime and 0.310-1.870 μg per spot for Potassium Clavulanate. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The % assay (Mean±S.D.) was found to be 100.29±0.9933 for Cefixime and 100.95±1.005 for Potassium Clavulanate.

Keywords

Cefixime, Potassium Clavulanate, HPTLC, Tablet Dosage Form.

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• Simultaneous Estimation of Aspirin and Atorvastatin Calcium in Capsule Dosage Form by Spectrophotometric Method

Abstract Views :186  |  PDF Views:0

Authors

R. K. Nanda ¹, S. E. Potawale ¹, V. V. Bhagwat ¹, S. C. Hamane ¹, R. S. Deshmukh ²

Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, IN
2 Sinhgad College of Pharmacy, Vadgaon, Pune-411041, IN

Source

Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 1041-1043

Abstract

A simple, precise and economical procedure for the simultaneous estimation of Aspirin and Atorvastatin Calcium in capsule formulation has been developed. The first method employs simultaneous equations (Method I) which involve absorbance measurement at 225.5 nm (λ max of Aspirin) and 246.0 (λ max of Atorvastatin Calcium). Second method involves absorbance ratio (Method II), which uses the ratio of absorbances measured at two selected wavelengths, one at isoabsorptive point (232.5 nm) and other being the max of one of the two compounds. Third method involves measurement of area under curve (AUC). For this method wavelength ranges were chosen between 223.5-227.5 nm and 244-248 nm for Aspirin and Atorvastatin Calcium respectively. Results of analysis for methods were tested and validated for various parameters according to ICH guidelines, hence can be adopted for the routine analysis of Aspirin and Atorvastatin Calcium in tablet dosage form.

Keywords

Aspirin, Atorvastatin Calcium, Simultaneous Equation Method, Absorbance Ratio Method, Area Under Curve Method.

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• Synthon Approach in Designing Organic Synthesis

Abstract Views :156  |  PDF Views:0

Authors

A. A. Kulkarni ¹, S. R. Doshi ¹, R. K. Nanda ¹, N. R. Chatterjee ²

Affiliations
1 Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, IN
2 Dr. D.Y. Patil College of Pharmacy, Akurdi, Pune-411044, Maharashtra, IN

Source

Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 1-4

Abstract

Synthon approach is a very useful analytical tool. It is an analytical approach to Organic Synthesis in which the target molecule is broken into fragments through a series of logical disconnection to get the best plausible and likely starting materials (ie. synthons or building blocks) for the target molecule. Synthesis is the real test of the organic medicinal chemist to use and control organic reactions. In each case the starting material is converted to some desired compound, the target molecule through some key intermediate. Actually, a number of synthetic routes can be written for a given target molecule. But in actual synthesis, generally that route is selected which is economical, safe, and easy to carry out and produces maximum yield in a short reaction time.

Keywords

Synthon Approach, Synthon, Disconnection Rules.

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• Estimation of Cefixime and Erdosteine in its Pharmaceutical Dosage Form by Spectrophotometric Method

Abstract Views :165  |  PDF Views:0

Authors

R. K. Nanda ¹, J. Gaikwad ¹, A. Prakash ¹, V. K. Ghosh ¹, D. H. Nagore ¹

Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, IN

Source

Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 404-406

Abstract

Two accurate and precise methods were developed for the estimation of Cefixime and Erdosteine in its pharmaceutical dosage form. First method is area under the curve method; the areas under the curve in the range of 294.5-284.5 nm (for CEF) and 240.0-230.0 nm (for ERD) were selected for the analysis. Second method is first order derivative spectroscopy by solving simultaneous equation, 309.0 nm (for CEF) and 227.5 nm (for ERD) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-50 μg/ml for both Cefixime and Erdosteine. The proposed methods were successfully applied for the simultaneous determination of both drugs in its pharmaceutical preparation. The results of the analysis have been validated statistically and by recovery studies.

Keywords

Cefixime, Erdosteine, Area Under the Curve Method, Derivative Spectroscopy.

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• Simultaneous Spectrophotometric Estimation of Tamsulosin in Pharmaceutical Dosage Form

Abstract Views :167  |  PDF Views:0

Authors

R. K. Nanda ¹, J. Gaikwad ¹, A. Prakash ¹

Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, IN

Source

Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 63-65

Abstract

Three simple, precise and economical UV methods have been developed for the estimation of Tamsulosin in pharmaceutical dosage form. Tamsulosin has the absorbance maxima at 281.0 nm (Method A), and in the first order derivative spectra, showed sharp peak at 234.5 nm (Method B). Method C applied was area under curve (AUC), in the wavelength range of 286.0-276.0 nm. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for all three methods. The proposed methods were successfully applied for the simultaneous determination of Tamsulosin in commercial pharmaceutical preparation. The results of the capsule analysis were validated statistically and by recovery studies. It was found to be satisfactory.

Keywords

Tamsulosin, Absorbance Maxima, Derivative Spectroscopy, Area Under Curve.

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